Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/13630
Title: Melatonin attenuates methamphetamine-induced inhibition of neurogenesis in the adult mouse hippocampus: An in vivo study
Authors: Singhakumar R.
Boontem P.
Ekthuwapranee K.
Sotthibundhu A.
Mukda S.
Chetsawang B.
Govitrapong P.
Keywords: beta tubulin
calcium calmodulin dependent protein kinase II
doublecortin
glial fibrillary acidic protein
melatonin
methamphetamine
mitogen activated protein kinase
n methyl dextro aspartic acid receptor
nestin
receptor subunit
central stimulant agent
melatonin
methamphetamine
n methyl dextro aspartic acid receptor
protein subunit
animal experiment
animal tissue
Article
controlled study
dentate gyrus
enzyme induction
hippocampus
in vivo study
learning
male
memory
mouse
nervous system development
nonhuman
priority journal
protein expression
signal transduction
subventricular zone
animal
C57BL mouse
cell differentiation
cell proliferation
drug effects
hippocampus
metabolism
nerve cell
nervous system development
neural stem cell
pathology
protein subunit
Animals
Cell Differentiation
Cell Proliferation
Central Nervous System Stimulants
Hippocampus
Male
MAP Kinase Signaling System
Melatonin
Methamphetamine
Mice, Inbred C57BL
Neural Stem Cells
Neurogenesis
Neurons
Protein Subunits
Receptors, N-Methyl-D-Aspartate
Issue Date: 2015
Abstract: Methamphetamine (METH), a highly addictive psychostimulant drug, is known to exert neurotoxic effects to the dopaminergic neural system. Long-term METH administration impairs brain functions such as cognition, learning and memory. Newly born neurons in the dentate gyrus of the hippocampus play an important role in spatial learning and memory. Previous in vitro studies have shown that METH inhibits cell proliferation and neurogenesis in the hippocampus. On the other hand, melatonin, a major indole secreted by the pineal gland, enhances neurogenesis in both the subventricular zone and dentate gyrus. In this study, adult C57BL/6 mice were used to study the beneficial effects of melatonin on METH-induced alterations in neurogenesis and post-synaptic proteins related to learning and memory functions in the hippocampus. The results showed that METH caused a decrease in neuronal phenotypes as determined by the expressions of nestin, doublecortin (DCX) and beta-III tubulin while causing an increase in glial fibrillary acidic protein (GFAP) expression. Moreover, METH inhibited mitogen-activated protein kinase (MAPK) signaling activity and altered expression of the N-methyl-. d-aspartate (NMDA) receptor subunits NR2A and NR2B as well as calcium/calmodulin-dependent protein kinase II (CaMKII). These effects could be attenuated by melatonin pretreatment. In conclusion, melatonin prevented the METH-induced reduction in neurogenesis, increase in astrogliogenesis and alteration of NMDA receptor subunit expression. These findings may indicate the beneficial effects of melatonin on the impairment of learning and memory caused by METH. © 2015 Elsevier Ireland Ltd.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941927186&doi=10.1016%2fj.neulet.2015.09.011&partnerID=40&md5=cfdd52abaed64e70bef24fa126a7b849
http://ir.swu.ac.th/jspui/handle/123456789/13630
ISSN: 3043940
Appears in Collections:SCOPUS 1983-2021

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