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Title: Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis
Authors: Yodying H.
Matsuda A.
Miyashita M.
Matsumoto S.
Sakurazawa N.
Yamada M.
Uchida E.
Keywords: Article
cancer patient
cancer prognosis
cancer surgery
cohort analysis
data base
disease free survival
esophagus cancer
esophagus surgery
lymph node metastasis
meta analysis
neutrophil lymphocyte ratio
observational study
outcome assessment
overall survival
platelet lymphocyte ratio
predictive value
retrospective study
systematic review
tumor invasion
cancer staging
Esophageal Neoplasms
multimodality cancer therapy
survival rate
Blood Platelets
Combined Modality Therapy
Esophageal Neoplasms
Neoplasm Staging
Survival Rate
Issue Date: 2016
Abstract: Background: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been reported to predict oncologic outcomes in patients with various types of cancer. However, their prognostic value in patients with esophageal cancer is unclear. In this meta-analysis, we evaluated the prognostic significance of NLR and PLR in esophageal cancer patients. Methods: We performed comprehensive searches of electronic databases to identify studies that evaluated the prognostic impact of pretreatment NLR and PLR in esophageal cancer patients. The end points were overall survival (OS), disease-free survival, and clinicopathologic parameters. A meta-analysis using random-effects models was performed to calculate hazard ratios (HRs) or odds ratios with 95 % confidence intervals (CIs). Results: Seven retrospective, observational, cohort studies involving 1540 patients were included. All seven studies evaluated NLR, and four evaluated PLR. Both high NLR (HR 1.40, 95 % CI 1.08–1.81, P = 0.01) and high PLR (HR 1.59, 95 % CI 1.14–2.21, P = 0.006) were significantly predictive of poorer OS. NLR was not a significant predictor of disease-free survival. High PLR (HR 1.85, 95 % CI 1.50–2.28, P < 0.00001) but not NLR was significantly predictive of poorer OS in a subgroup of patients who underwent curative surgery without neoadjuvant chemoradiation. Both high NLR and high PLR were significantly associated with deeper tumor invasion and lymph node metastasis. Conclusions: NLR and PLR are associated with tumor progression and are predictive of poorer survival in patients with esophageal cancer. These ratios may thus help to inform treatment decisions and predict treatment outcomes. © 2015, Society of Surgical Oncology.
ISSN: 10689265
Appears in Collections:SCOPUS 1983-2021

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