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https://ir.swu.ac.th/jspui/handle/123456789/13345| Title: | Effect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy |
| Authors: | Hirunsai M. Yimlamai T. Suksamrarn A. |
| Keywords: | ecdysterone muscle protein muscle RING finger 1 protein ecdysterone ubiquitinated protein achilles tendon adult animal experiment animal model animal tissue Article body weight controlled study histology male muscle atrophy muscle mass muscle wet weight nonhuman plantaris muscle protein degradation protein expression rat skeletal muscle soleus muscle tenotomy ubiquitination Western blotting animal drug effects metabolism muscle atrophy pathology protein degradation randomization signal transduction skeletal muscle subcutaneous drug administration Wistar rat Animals Blotting, Western Ecdysterone Injections, Subcutaneous Male Muscle, Skeletal Muscular Atrophy Proteolysis Random Allocation Rats, Wistar Signal Transduction Tenotomy Ubiquitinated Proteins Ubiquitination |
| Issue Date: | 2016 |
| Abstract: | Background/Aim: 20-Hydroxyecdystone (20E) is an ecdysteroid hormone which controls molting and reproduction in arthropods. 20E also produces a variety of effects in vertebrates, including enhancing protein synthesis and skeletal muscle regeneration. The effect of 20E on disuse muscle atrophy has not been reported to date. This study examined the proteolytic regulation of 20E in tenotomized rat slow soleus and fast plantaris muscles. Materials and Methods: Male Wistar rats were randomly divided into three groups: sedentary control (CON), tenotomy without 20E treatment (TEN), and tenotomy with treatment of 5 mg/kg BW of 20E (TEN+20E). The TEN+20E group was administered 20E via subcutaneous injection to the right thigh for 7 days after tenotomy. Results: 20E treatment tended to attenuate disuse muscle atrophy and reduced ubiquitination only in soleus muscle. Conclusion: 20E treatment alleviates skeletal muscle atrophy partially mediated by ubiquitinate pathway, dependent on the muscle phenotype. © 2016, International Institute of Anticancer Research. All rights reserved. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/13345 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994246675&doi=10.21873%2finvivo.11007&partnerID=40&md5=6a1b5fcb0dcc58301598696d69588ae3 |
| ISSN: | 0258851X |
| Appears in Collections: | Scopus 1983-2021 |
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