Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/13262
Title: Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years
Authors: Limkunakul C.
Srinithiwat P.
Lochinda B.
Sawanyawisuth K.
Keywords: atazanavir
didanosine
efavirenz
indinavir
lamivudine
lopinavir plus ritonavir
nevirapine
stavudine
tenofovir
tenofovir disoproxil
zidovudine
anti human immunodeficiency virus agent
biological marker
adult
Article
body mass
clinical feature
coronary artery disease
creatinine blood level
cryptococcosis
diabetes mellitus
disease course
disease transmission
environmental monitoring
estimated glomerular filtration rate
female
genetic association
human
Human immunodeficiency virus infection
hypertension
major clinical study
male
middle aged
mortality
multivariate analysis
outcome assessment
receiver operating characteristic
retrospective study
risk factor
sensitivity and specificity
age
chronic kidney failure
comorbidity
complication
glomerulus filtration rate
highly active antiretroviral therapy
Human immunodeficiency virus infection
mixed infection
prognosis
Thailand
virology
Adult
Age Factors
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Biomarkers
Coinfection
Comorbidity
Female
Glomerular Filtration Rate
HIV Infections
Humans
Male
Middle Aged
Prognosis
Renal Insufficiency, Chronic
Retrospective Studies
ROC Curve
Thailand
Issue Date: 2017
Abstract: Chronic kidney disease (CKD) has been shown to be a poor prognostic factor in HIV patients. This study aimed to identify risk factors in HIV-infected patients with early decline in renal function or an estimated glomerular filtration rate (eGFR) less than 90 mL/min/1.73 m2. The study was retrospectively conducted at Panyananthaphikkhu Chonprathan Medical Center, Thailand. The inclusion criteria were HIV-infected adult patients who were treated at the hospital’s HIV clinic and whose eGFR levels at the first visit had been evaluated. Eligible patients were categorized according to their eGFR level being lesser or greater than 90 mL/min/1.73 m2. Multivariate logistic analysis was performed to evaluate the association of risk factors with an eGFR of less than 90 mL/min/1.73 m2. There were 301 HIV-infected patients included in the study. Of those, 89 patients (29.57%) had an eGFR of less than 90 mL/min/1.73 m2. Age was the only significant risk factor associated with an eGFR of less than 90 mL/ min/1.73 m2 with an adjusted odds ratio of 1.072 (95% confidence interval: 1.015–1.132). Age of over 37 years predicted an eGFR of less than 90 mL/min/1.73 m2 as a risk factor in HIV-infected patients, with a sensitivity of 80.9% and specificity of 34.91%. Age was independently associated with eGFRs of less than 90 mL/min/1.73 m2 in HIV-infected patients. Close monitoring of eGFR should be performed in HIV-infected patients aged over 37 years. © 2017, National Institute of Health. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85035146945&doi=10.7883%2fyoken.JJID.2016.370&partnerID=40&md5=851e761717c30539b60d87f53d9e6554
http://ir.swu.ac.th/jspui/handle/123456789/13262
ISSN: 13446304
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.