Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/12983
Title: Molecular analysis of haemoglobin E in Southeast Asian populations
Authors: Jomoui W.
Fucharoen G.
Sanchaisuriya K.
Nguyen N.T.
Nguyen H.V.
Fucharoen S.
Keywords: chromosome
gene expression
genetic analysis
hemoglobin
molecular analysis
phylogenetics
Cambodia
China
Europe
India
South Asia
Thailand
Yunnan
Laotia
hemoglobin E
allele
genetics
haplotype
human
phylogeny
Southeast Asia
Alleles
Asia, Southeastern
Haplotypes
Hemoglobin E
Humans
Phylogeny
Issue Date: 2017
Abstract: Haemoglobin (Hb) E is the most common Hb variant in Asia where its gene frequency approaches 0.3 in some areas. We studied genetic background of Hb E genes among Southeast Asian populations. This study examined β-globin gene haplotypes linked to haemoglobin E (Hb E) in diverse groups of Southeast Asian populations. The study was conducted on southern Thai (22 alleles), Cambodian (84 alleles), Laotian (120 alleles), Vietnamese (87 alleles) and Burmese (one allele) subjects. Results were compared with those of previous studies in northeast Thailand, the Yunnan of China, West India and Europe. Ten different haplotypes were observed. The four most common haplotypes were haplotypes 1 (– +–+ + + –) and 2 (+–––– + –) on chromosomes with framework 2 and haplotypes 6 (– +–+ +–+) and 7 (+–––––+) on chromosomes with framework 3 variety. Phylogenetic analysis indicated that haplotype 1 is a relatively recent haplotype found in all populations, whereas haplotype 6 is found predominately in Cambodians. The results indicate that at least two genetic origins of Hb E are responsible for the high prevalence and spread of Hb E among Southeast Asian populations. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031780244&doi=10.1080%2f03014460.2017.1388844&partnerID=40&md5=c9477ace403c82eb9435c294d4c7594f
http://ir.swu.ac.th/jspui/handle/123456789/12983
ISSN: 3014460
Appears in Collections:Scopus 1983-2021

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