Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/12942
Title: Metabolic effects of diet and exercise in patients with moderate to severe CKD: A randomized clinical trial
Authors: Alp Ikizler T.
Robinson-Cohen C.
Ellis C.
Headley S.A.E.
Tuttle K.
Wood R.J.
Evans E.E.
Milch C.M.
Moody K.A.
Germain M.
Limkunakul C.
Bian A.
Stewart T.G.
Himmelfarb J.
Keywords: albumin
creatinine
interleukin 6
isoprostane derivative
oxygen
creatinine
IL6 protein, human
interleukin 6
isoprostane derivative
adult
aerobic exercise
aged
Article
blood level
body weight
caloric restriction
chronic kidney failure
clinical outcome
controlled study
diabetes mellitus
fat mass
female
human
hypertension
major clinical study
male
oxygen consumption
pilot study
priority journal
randomized controlled trial
albuminuria
blood
chronic kidney failure
exercise
glomerulus filtration rate
middle aged
obesity
oxidative stress
pathophysiology
physiology
urine
Adiposity
Aged
Albuminuria
Body Weight
Caloric Restriction
Creatinine
Exercise
F2-Isoprostanes
Female
Glomerular Filtration Rate
Humans
Interleukin-6
Male
Middle Aged
Oxidative Stress
Oxygen Consumption
Pilot Projects
Renal Insufficiency, Chronic
Issue Date: 2018
Abstract: CKD is steadily increasing along with obesity worldwide. Furthermore, obesity is a proinflammatory risk factor for progression of CKD and cardiovascular disease. We tested the hypothesis that implementation of caloric restriction and aerobic exercise is feasible and can improve the proinflammatory metabolic milieu in patients with moderate to severe CKD through a pilot, randomized, 232 factorial design trial. Of 122 participants consented, 111 were randomized to receive caloric restriction and aerobic exercise, caloric restriction alone, aerobic exercise alone, or usual care. Of those randomized, 42% were women, 25% were diabetic, and 91% were hypertensive; 104 started intervention, and 92 completed the 4-month study. Primary outcomes were a change from baseline in absolute fat mass, body weight, plasma F2-isoprostane concentrations, and peak oxygen uptake (VO2 peak). Compared with usual care, the combined intervention led to statistically significant decreases in body weight and body fat percentage. Caloric restriction alone also led to significant decreases in these measures, but aerobic exercise alone did not. The combined intervention and each independent intervention also led to significant decreases in F2-isoprostane and IL-6 concentrations. No intervention produced significant changes in VO2 peak, kidney function, or urine albumin-to-creatinine ratio. In conclusion, 4-month dietary calorie restriction and aerobic exercise had significant, albeit clinically modest, benefits on body weight, fat mass, and markers of oxidative stress and inflammatory response in patients with moderate to severe CKD. These results suggest healthy lifestyle interventions as a nonpharmacologic strategy to improve markers of metabolic health in these patients. Copyright © 2018 by the American Society of Nephrology.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040117215&doi=10.1681%2fASN.2017010020&partnerID=40&md5=0650c3afb503d6b98a4c69548f88e7ea
http://ir.swu.ac.th/jspui/handle/123456789/12942
ISSN: 10466673
Appears in Collections:Scopus 1983-2021

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