Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/12615
Title: Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
Authors: Paiboonvong T.
Nosoongnoen W.
Sathirakul K.
Tangsujaritvijit V.
Kaemapairoj J.
Tragulpiankit P.
Montakantikul P.
Keywords: sitafloxacin
antiinfective agent
quinolone derivative
sitafloxacin
adult
aged
area under the curve
Article
blood sampling
clinical article
critically ill patient
drug blood level
drug penetration
elimination half-life
elimination rate constant
epithelial lining fluid
female
human
liquid
lung lavage fluid
male
oral clearance
pharmacokinetic parameters
pneumonia
priority journal
single drug dose
Thai (citizen)
time to maximum plasma concentration
volume of distribution
bronchoalveolar lavage fluid
critical illness
drug effect
lung
lung alveolus macrophage
lung lavage
metabolism
microbiology
middle aged
pneumonia
procedures
respiratory mucosa
Thailand
Adult
Aged
Anti-Bacterial Agents
Bronchoalveolar Lavage
Bronchoalveolar Lavage Fluid
Critical Illness
Female
Fluoroquinolones
Humans
Lung
Macrophages, Alveolar
Male
Middle Aged
Pneumonia
Respiratory Mucosa
Thailand
Issue Date: 2019
Abstract: Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.) Copyright © 2019 American Society for Microbiology. All Rights Reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072588748&doi=10.1128%2fAAC.00800-19&partnerID=40&md5=62351e29caba94e1451796b151040b0e
http://ir.swu.ac.th/jspui/handle/123456789/12615
ISSN: 664804
Appears in Collections:Scopus 1983-2021

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