Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/12419
Title: Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans
Authors: Treesirichod A.
Chaithirayanon S.
Wongjitrat N.
Keywords: adapalene
retinoic acid
adapalene
dermatological agent
keratolytic agent
retinoic acid
skin cream
acanthosis nigricans
adolescent
Article
body weight change
child safety
clinical article
controlled study
double blind procedure
drug efficacy
drug safety
female
human
hyperpigmentation
male
outcome assessment
priority journal
randomized controlled trial
acanthosis nigricans
child
comparative study
cutaneous drug administration
gel
neck
treatment outcome
Acanthosis Nigricans
Adapalene
Administration, Cutaneous
Adolescent
Child
Dermatologic Agents
Double-Blind Method
Female
Gels
Humans
Keratolytic Agents
Male
Neck
Skin Cream
Treatment Outcome
Tretinoin
Issue Date: 2019
Abstract: Background: There have been few published randomized controlled trials for the treatment of childhood acanthosis nigricans (AN) to date. Objective: To assess the efficacy of topical 0.1% adapalene gel compared to 0.025% tretinoin cream in the treatment of childhood AN. Methods: An 8-week, randomized, split-neck, comparative study between topical 0.1% adapalene gel and 0.025% tretinoin cream for the treatment of neck hyperpigmentation associated with AN was performed. M index measured by a narrowband reflectance spectrophotometer and both investigator's global evaluation (IGE) and parent's global evaluation (PGE) scales were used to evaluate efficacy. Results: There was no statistically significant difference between 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of AN-associated hyperpigmentation (P = 0.56). Mean differences in M indices between week 0 and week 8 of 0.1% adapalene and 0.025% tretinoin treatment were 24.2 ± 7.9% and 23.8 ± 8.3% improvement, respectively. Regarding treatment efficacy, 90.0% and 85.0% of participants had more than 75% improvement in IGE in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively. In addition, 75.0% and 65.0% of participants had more than 75.0% improvement in PGE in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively. Limitations: Lack of histopathological evaluations. Conclusions: We found no significant difference between topical 0.1% adapalene gel and 0.025% tretinoin in the treatment of AN. © 2019 Wiley Periodicals, Inc.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065863410&doi=10.1111%2fpde.13799&partnerID=40&md5=9e68ab3bbdc165548b7b203fc4a66626
http://ir.swu.ac.th/jspui/handle/123456789/12419
ISSN: 7368046
Appears in Collections:Scopus 1983-2021

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