Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/12175
Title: Characteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group
Authors: Wudhikarn K.
Bunworasate U.
Julamanee J.
Lekhakula A.
Ekwattanakit S.
Khuhapinant A.
Chuncharunee S.
Niparuck P.
Numbenjapon T.
Prayongratana K.
Kanitsap N.
Wongkhantee S.
Makruasi N.
Wong P.
Norasetthada L.
Nawarawong W.
Sirijerachai C.
Chansung K.
Suwanban T.
Praditsuktavorn P.
Intragumtornchai T.
on behalf of Thai Lymphoma Study Group
Keywords: asparaginase
cyclophosphamide
dexamethasone
doxorubicin
etoposide
ifosfamide
methotrexate
prednisolone
steroid
vincristine
adult
aged
aging
Article
cancer chemotherapy
cancer combination chemotherapy
cancer prognosis
cancer radiotherapy
cancer registry
cohort analysis
comorbidity
controlled study
diarrhea
drug dose escalation
drug fatality
drug safety
febrile neutropenia
female
follow up
geriatric assessment
groups by age
human
ileus
infection
intensive care
long term survival
major clinical study
male
multiple cycle treatment
neuropathy
neutropenia
NK T cell lymphoma
nonhodgkin lymphoma
oral mucositis
overall survival
peripheral T cell lymphoma
physical performance
polypharmacy
priority journal
progression free survival
Thailand
thrombocytopenia
treatment outcome
Issue Date: 2020
Abstract: Introduction: Peripheral T cell NHL (PTCL) and natural killer/T cell NHL (NKTCL) are relatively rare disorders. Data on clinical presentation, treatment and outcome are limited especially in older age groups. Methods: We identified 127 patients with PTCL and NKTCL, excluding cutaneous T/NK cell lymphoma, aged over 60 years old from Thailand nationwide multicenter registry. Results: Of 127 patients, median age of diagnosis was 67 years old. Patients aged older than 75 years old had similar characteristics to younger (60–74 years old) but higher comorbidity index. Seventy-nine patients (62.2%) received intensive/definite multi-agent chemotherapy, however, the proportion was significant lower in older patients (70.4% vs 34.5%, p <. 001). After a median follow up duration of 17.3 months, 2-year progression free survival and overall survival were 38.1% and 48.5%. Univariate and multivariable analysis demonstrated older age, poor performance status and absence of definite multi-agent chemotherapy were associated with inferior survival. Definite multi-agent lymphoma specific chemotherapy was an independent factor for overall survival after adjustment for age, comorbidity index, performance status and prognostic index for T cell lymphoma. Conclusion: Despite overall poor prognosis of PTCL and NKTCL in older adults, chemotherapy could result in objective response and long-term survival in selected patients of this vulnerable age group thus emphasizing the importance of comprehensive geriatric evaluation. © 2019
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063582476&doi=10.1016%2fj.jgo.2019.03.016&partnerID=40&md5=3ef0840820bce919d55b06f2fc54bb86
http://ir.swu.ac.th/jspui/handle/123456789/12175
ISSN: 18794068
Appears in Collections:SCOPUS 1983-2021

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