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https://ir.swu.ac.th/jspui/handle/123456789/11998| Title: | Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37 |
| Authors: | Noppawan S. Mongkolthanaruk W. Suwannasai N. Senawong T. Moontragoon P. Boonmak J. Youngme S. McCloskey S. |
| Keywords: | cytochalasin fungal extract pentaminolarin pentapeptide xylochalasin antineoplastic agent cyclopeptide cytochalasin controlled study cytotoxicity density functional theory drug purification drug structure HCT 116 cell line HeLa cell line HT-29 cell line human human cell IC50 MTT assay nonhuman Thailand Vero cell line Xylariales chemistry conformation drug screening isolation and purification pathogenicity tumor cell line Antineoplastic Agents Cell Line, Tumor Cytochalasins Drug Screening Assays, Antitumor Humans Molecular Conformation Peptides, Cyclic Xylariales |
| Issue Date: | 2020 |
| Abstract: | A new cyclic pentapeptide, pentaminolarin (1), and a new cytochalasin, xylochalasin (2), along with thirteen known compounds (3–15) were isolated from the wood-decaying fungus Xylaria sp. SWUF08-37. The absolute configurations of 1 were determined by a combination of Marfey’s method and TDDFT ECD calculation and the absolute configurations of 2 were established by TDDFT ECD calculation. Compound 12 showed moderate cytotoxicity against HeLa (IC50 = 19.60 µg/mL), HT29 (IC50 = 17.31 µg/mL), HCT116 (IC50 = 14.28 µg/mL), MCF-7 (IC50 = 15.38 µg/mL), and Vero (IC50 = 24.97 µg/mL) cell lines by MTT assay. Compounds 1 and 2 showed slight cytotoxicity against all tested cancer cell lines. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/11998 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053874640&doi=10.1080%2f14786419.2018.1488709&partnerID=40&md5=09eec464f381ef64953383ac92d1500f |
| ISSN: | 14786419 |
| Appears in Collections: | Scopus 1983-2021 |
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