Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/11973
Title: Wide electrochemical window of screen-printed electrode for determination of rapamycin using ionic liquid/graphene composites
Authors: Chaiyo S.
Jampasa S.
Thongchue N.
Mehmeti E.
Siangproh W.
Chailapakul O.
Kalcher K.
Keywords: graphite
ionic liquid
rapamycin
blood
devices
electrochemical analysis
electrode
limit of detection
procedures
urine
Electrochemical Techniques
Electrodes
Graphite
Ionic Liquids
Limit of Detection
Sirolimus
Issue Date: 2020
Abstract: A disposable screen-printed carbon electrode (SPCE) modified with an ionic liquid/graphene composite (IL/G) exhibits a wider potential window, excellent conductivity, and specific surface area for the improvement in the voltammetric signal of rapamycin detection. The modified composite was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and electrochemical impedance spectroscopy (EIS). The electrochemical behavior of rapamycin at the modified SPCE was investigated by cyclic and square wave voltammetry in 60:40 EtOH: 0.1 M LiClO4 at pH 5.0. A high reproducible and well-defined peak with a high peak current were obtained for rapamycin detection at a position potential of + 0.98 V versus Ag/AgCl. Under the optimized conditions, the rapamycin concentration in the range 0.1 to 100 μM (R2 = 0.9986) had a good linear relation with the peak current. The detection limit of this method was 0.03 μM (3SD/slope). The proposed device can selectively detect rapamycin in the presence of commonly interfering compounds. Finally, the proposed method was successfully applied to determine rapamycin in urine and blood samples with excellent recoveries. These devices are disposable and cost-effective and might be used as an alternative tool for detecting rapamycin in biological samples and other biological compounds. [Figure not available: see fulltext.] © 2020, Springer-Verlag GmbH Austria, part of Springer Nature.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380838&doi=10.1007%2fs00604-020-4190-2&partnerID=40&md5=33bcd02998f3a750890a48f8b8156342
http://ir.swu.ac.th/jspui/handle/123456789/11973
ISSN: 263672
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.