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Title: Optical Bioelectronic Device Based on a Screen-Printed Electroluminescent Transducer
Authors: Yakoh A.
Siangproh W.
Chailapakul O.
Ngamrojanavanich N.
Keywords: Antibodies
Indium compounds
Optoelectronic devices
Tin oxides
Alternating current
Bioelectronic device
Cardio-vascular disease
Electronic conduction
Immobilized antibodies
Indium tin oxide electrodes
Inflammatory process
Point-of-care testing
Flexible displays
Issue Date: 2020
Abstract: A new class of biosensing transducer based on alternating-current electroluminescent (ACEL) display is demonstrated. Unlike conventional ACEL displays where they have been rigidly used in flexible screens and advertising applications, here, the display is integrated with immunoassay and functioned as an optical transducer. Taking advantage of the reversed ACEL architecture, the display can be simply fabricated on an unconventional paper material without requiring the transparent indium tin oxide (ITO) electrode. The sensing mechanism relies on the promoted electronic conduction from the immunocomplex formation between immobilized antibody, antigen, and nanoparticle labeled antibody. As a result, the electroluminescence could be triggered off instantaneously. To demonstrate the device effectiveness, C-reactive protein (CRP), a particular biomarker of an inflammatory process and cardiovascular disease, is chosen as a model analyte in this work. Additionally, the applicability of the proposed platform is proved efficacious in human serums, showing negligible interference from nontargeting proteins. The sensing display is also capable of performing multiple assays (up to 8) within a single device. This bio-optoelectronic device represents a straightforward yet highly sensitive approach. This ACEL transducer is believed to explore new possibilities for biosensing and exploit in point-of-care testing. © 2020 American Chemical Society.
ISSN: 19448244
Appears in Collections:SCOPUS 1983-2021

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