Please use this identifier to cite or link to this item: http://ir.swu.ac.th/jspui/handle/123456789/11885
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dc.contributor.authorLeerapongnan P.
dc.contributor.authorJurairattanaporn N.
dc.contributor.authorKanokrungsee S.
dc.contributor.authorUdompataikul M.
dc.date.accessioned2021-04-05T03:01:22Z-
dc.date.available2021-04-05T03:01:22Z-
dc.date.issued2020
dc.identifier.issn2688921
dc.identifier.other2-s2.0-85078302901
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85078302901&doi=10.1007%2fs10103-019-02944-9&partnerID=40&md5=77e272087e1ff326e326789f8ddf1759
dc.identifier.urihttp://ir.swu.ac.th/jspui/handle/123456789/11885-
dc.description.abstractAcanthosis nigricans is a common dermatological problem. There are currently limited clinical trials to determine the efficacy and safety of laser treatments. To compare the efficacy of fractional 1550-nm erbium fiber laser versus 0.05% tretinoin cream for the treatment of acanthosis nigricans at neck, a randomized, controlled, assessor-blinded study was conducted in 18 subjects with acanthosis nigricans at the neck. All patients were treated with both fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream on each side of the neck. The laser side was treated with three treatment sessions, with a 4-week interval of 1550-nm fractional erbium laser. Another side was treated with 0.05% tretinoin cream daily at bedtime for 12 weeks. We evaluated at baseline, with a 4-week interval until 4 weeks after the last treatment. The efficacy was assessed by skin color ratio, melanin index, average roughness, photographic evaluation, patients’ satisfaction, and the adverse effects. At the study endpoint, week 12, the mean Visiometer-average roughness showed greater reduction in laser-treated side (24.65%) than tretinoin side (22.94%) (p = 0.004). Laser-treated side also showed greater percentage of skin color ratio reduction, melanin index reduction, and better mean of photographic-based evaluation percentage change from the baseline than tretinoin side with no significant different (p = 0.331, p = 0.116, p = 0.327, respectively). The study showed one post-inflammatory hyperpigmentation in tretinoin side. Regarding to the average roughness, fractional 1550-nm erbium fiber laser was superior to 0.05% tretinoin cream for treatment of neck-acanthosis nigricans with less side effect. Fractional 1550-nm erbium fiber laser could be considered as an alternative treatment for acanthosis nigricans. © 2020, Springer-Verlag London Ltd., part of Springer Nature.
dc.subjectmelanin
dc.subjectretinoic acid
dc.subjecterbium
dc.subjectmelanin
dc.subjectretinoic acid
dc.subjectacanthosis nigricans
dc.subjectadult
dc.subjectArticle
dc.subjectbedtime dosage
dc.subjectclinical article
dc.subjectclinical outcome
dc.subjectcomparative effectiveness
dc.subjectcontrolled study
dc.subjectcream
dc.subjecterythema
dc.subjectfemale
dc.subjecthuman
dc.subjectlow level laser therapy
dc.subjectmale
dc.subjectneck
dc.subjectpatient safety
dc.subjectpatient satisfaction
dc.subjectpostinflammatory hyperpigmentation
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectrandomized controlled trial
dc.subjectsingle blind procedure
dc.subjectskin color
dc.subjectskin irritation
dc.subjectacanthosis nigricans
dc.subjectcomparative study
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectmultimodality cancer therapy
dc.subjectsolid state laser
dc.subjecttreatment outcome
dc.subjectyoung adult
dc.subjectAcanthosis Nigricans
dc.subjectAdult
dc.subjectCombined Modality Therapy
dc.subjectErbium
dc.subjectFemale
dc.subjectHumans
dc.subjectLasers, Solid-State
dc.subjectMale
dc.subjectMelanins
dc.subjectMiddle Aged
dc.subjectPatient Satisfaction
dc.subjectProspective Studies
dc.subjectTreatment Outcome
dc.subjectTretinoin
dc.subjectYoung Adult
dc.titleComparison of the effectiveness of fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream in the treatment of acanthosis nigricans: a prospective, randomized, controlled trial
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationLasers in Medical Science. Vol 35, No.5 (2020), p.1153-1158
dc.identifier.doi10.1007/s10103-019-02944-9
Appears in Collections:Scopus 1983-2021

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