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Title: An exploration of ABCG2 and SLC2A9 gene interactions with gout
Authors: Khuancharee K.
Tanunyutthawongse C.
Wannaiampikul S.
Keywords: high density lipoprotein cholesterol
low density lipoprotein cholesterol
ABCG2 gene
body mass
case control study
cholesterol blood level
controlled study
diastolic blood pressure
gene interaction
genetic association
genetic variability
genome-wide association study
major clinical study
middle aged
sample size
single nucleotide polymorphism
SLC2A9 gene
systolic blood pressure
Issue Date: 2020
Abstract: Background: Currently, there is no systematic analysis of single nucleotide polymorphisms (SNPs) in the urate transporter genes (ABCG2 and SLC2A9), and the influence of their combination and gene-gene (G×G) interactions on gout is still unknown in the Thai population. Objective: To investigate the interaction between ABCG2 and SLC2A9 with gout. Materials and Methods: A matched case-control study with 116 Thai adults (58 gout patients and 58 control subjects) was done. Genotyping using a TaqMan SNP Genotyping Assays was performed. G×G interactions for gout risk were analyzed using an interaction analysis in multiple conditional logistic regression. Results: The results show that the rs2231142 (G/T+T/T) variants in ABCG2 was associated with gout. On the contrary, the rs2280205 (G/A+A/A) and rs6820230 (C/T-T/T) variant in SLC2A9 were not associated with gout. The result indicated that the participants carrying ABCG2 variant with SLC2A9 wild-type (i.e., original base pairs) had a significant association with gout. The present study results also revealed that epistatic interaction pairs (rs2231142:rs6820230 and rs2231142:rs2280205) were strongly associated with gout. Conclusion: The authors concluded that the ABCG2 and SLC2A9 interactions were a significant association with gout. The stronger combined effect of SNPs in the ABCG2 and SLC2A9 genes via G×G interaction may help to predict gout risk and its prognosis. However, further studies with larger sample sizes should be performed to confirm these results. © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND | 2020.
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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